From bench to bedside: The mGluR5 system in people with and without Autism Spectrum Disorder and animal model systems

Journal article

F] FPEB binding (t (13) = -2.86, p = 0.047) in the left striatum/thalamus region of interest as compared to controls. Within this region, there was a strong negative correlation between GABA + and mGluR5 density across the entire cohort (Pearson's correlation: r (14) = -0.763, p = 0.002). Cntnap2 KO mice had significantly higher mGlu5 receptor binding in the striatum (caudate-putamen) as compared to wild-type (WT) mice (n = 15, p = 0.03). There were no differences in mGluR5 binding for mice with the Shank3 knockout or 16p11.2 deletion. Given that Cntnap2 is associated with a specific striatal deficit of parvalbumin positive GABA interneurons and 'autistic' features, our findings suggest that an increase in mGluR5 in ASD may relate to GABAergic interneuron abnormalities.

Authors: Carey, C; Singh, N; Dunn, JT; Sementa, T; Mendez, MA

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Springer Nature [academic journals on nature.com]
• Journal: Translational Psychiatry
• Volume: 12
• Issue: 1
• Pages: 395-395
• Article number: 395
• Publication date: 2022-09-20
• DOI: 10.1038/s41398-022-02143-1
• EISSN: 2158-3188
• ISSN: 2158-3188
• Language: English
• Keywords: Neuroscience; Biology; Putamen; Metabotropic glutamate receptor 5; Medicine; Internal medicine; Metabotropic glutamate receptor; Dopamine; Receptor; Striatum; Psychology; Glutamate receptor