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Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1.

Abstract:

Glucocorticoids (GCs), which are used in the treatment of immune-mediated inflammatory diseases, inhibit the expression of many inflammatory mediators. They can also induce the expression of dual specificity phosphatase 1 (DUSP1; otherwise known as mitogen-activated protein kinase [MAPK] phosphatase 1), which dephosphorylates and inactivates MAPKs. We investigated the role of DUSP1 in the antiinflammatory action of the GC dexamethasone (Dex). Dex-mediated inhibition of c-Jun N-terminal kinase...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20060336

Authors


Abraham, SM More by this author
Lawrence, T More by this author
Kleiman, A More by this author
Medghalchi, M More by this author
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Journal:
The Journal of experimental medicine
Volume:
203
Issue:
8
Pages:
1883-1889
Publication date:
2006-08-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:fc34721e-3bbc-4fcd-b7b5-eba24742088a
Source identifiers:
226695
Local pid:
pubs:226695

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