- Abstract:
-
Glucocorticoids (GCs), which are used in the treatment of immune-mediated inflammatory diseases, inhibit the expression of many inflammatory mediators. They can also induce the expression of dual specificity phosphatase 1 (DUSP1; otherwise known as mitogen-activated protein kinase [MAPK] phosphatase 1), which dephosphorylates and inactivates MAPKs. We investigated the role of DUSP1 in the antiinflammatory action of the GC dexamethasone (Dex). Dex-mediated inhibition of c-Jun N-terminal kinase...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1084/jem.20060336
-
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- Journal:
- The Journal of experimental medicine
- Volume:
- 203
- Issue:
- 8
- Pages:
- 1883-1889
- Publication date:
- 2006-08-05
- DOI:
- EISSN:
-
1540-9538
- ISSN:
-
0022-1007
- URN:
-
uuid:fc34721e-3bbc-4fcd-b7b5-eba24742088a
- Source identifiers:
-
226695
- Local pid:
- pubs:226695
- Language:
- English
- Keywords:
- Copyright date:
- 2006
Journal article
Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1.
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