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Fosphenytoin for seizure prevention in childhood coma in Africa: a randomized clinical trial.

Abstract:

PURPOSE: We conducted a double-blind trial to determine whether a single intramuscular injection of fosphenytoin prevents seizures and neurologic sequelae in children with acute coma. METHODS: We conducted this study at Kilifi District Hospital in coastal Kenya and Kondele Children's Hospital in western Kenya. We recruited children (age, 9 months to 13 years) with acute nontraumatic coma. We administered fosphenytoin (20 phenytoin equivalents/kg) or placebo and examined the prevalence and fre...

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Publication status:
Published

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Publisher copy:
10.1016/j.jcrc.2013.09.001

Authors


Chengo, EM More by this author
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Journal:
Journal of critical care
Volume:
28
Issue:
6
Pages:
1086-1092
Publication date:
2013-12-05
DOI:
EISSN:
1557-8615
ISSN:
0883-9441
URN:
uuid:fc3026f6-dd27-4249-9d52-67e90b7da1eb
Source identifiers:
434396
Local pid:
pubs:434396

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