Journal article
In-depth immunophenotyping data of IL-6R on the human peripheral regulatory T cell (Treg) compartment
- Abstract:
- We provide in this paper a detailed characterization of the human peripheral CD4+ CD127lowCD25+ regulatory T cell (Treg) compartment, with a particular emphasis in defining the population expressing higher levels of the IL-6 receptor (IL-6R). We provide a description of the phenotype of this population by assessing both the surface expression by flow cytometry as well as their transcriptional profile and functional features. In addition, we also present functional data describing the responsiveness of these subsets to IL-6 signalling in vitro and to IL-2 in vivo. The data presented in this paper support the research article “Human IL-6RhiTIGIT− CD4+CD127lowCD25+ T cells display potent in vitro suppressive capacity and a distinct Th17 profile
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.8MB, Terms of use)
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- Publisher copy:
- 10.1016/j.dib.2017.04.043
Authors
- Publisher:
- Elsevier
- Journal:
- Data in Brief More from this journal
- Volume:
- 12
- Pages:
- 676–691
- Publication date:
- 2017-05-01
- Acceptance date:
- 2017-04-24
- DOI:
- EISSN:
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2352-3409
- Keywords:
- Pubs id:
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pubs:691082
- UUID:
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uuid:fc20315a-9168-4f48-a6e6-4ea767c43d75
- Local pid:
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pubs:691082
- Deposit date:
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2017-04-24
Terms of use
- Copyright holder:
- Ferreira et al
- Copyright date:
- 2017
- Notes:
- © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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