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Estimation of maximal affinities between T-cell receptors and MHC/peptide complexes.

Abstract:

Recognition of peptide/MHC complexes by T-cell receptors (TCRs) is a critical step for T-cell activation. We studied T-cell activation as a function of this interaction using a mathematical model. Unlike other models analysing TCR-MHC/peptide interactions, this study takes into account that both TCRs and MHC/peptide complexes are anchored in membranes and not in solution. The proposed model quantitatively predicts several essential features of antigen-specific T-cell activation, including the...

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Publication status:
Published

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Journal:
Molecular immunology More from this journal
Volume:
35
Issue:
2
Pages:
65-71
Publication date:
1998-02-01
DOI:
EISSN:
1872-9142
ISSN:
0161-5890
Language:
English
Keywords:
Pubs id:
pubs:469243
UUID:
uuid:fc0dbbdf-62b1-4394-a94f-3de0554bb4a3
Local pid:
pubs:469243
Source identifiers:
469243
Deposit date:
2014-06-17

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