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Local field potential activity dynamics in response to deep brain stimulation of the subthalamic nucleus in Parkinson's disease

Abstract:

Local field potentials (LFPs) may afford insight into the mechanisms of action of deep brain stimulation (DBS) and potential feedback signals for adaptive DBS. In Parkinson's disease (PD) DBS of the subthalamic nucleus (STN) suppresses spontaneous activity in the beta band and drives evoked resonant neural activity (ERNA). Here, we investigate how STN LFP activities change over time following the onset and offset of DBS. To this end we recorded LFPs from the STN in 14 PD patients during long ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Publisher:
Elsevier
Journal:
Neurobiology of Disease More from this journal
Volume:
143
Article number:
105019
Publication date:
2020-07-16
Acceptance date:
2020-07-11
DOI:
ISSN:
0969-9961
Language:
English
Keywords:
Pubs id:
1120498
Local pid:
pubs:1120498
Deposit date:
2020-07-20

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