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Structural basis for the acceleration of procollagen processing by Procollagen C-Proteinase Enhancer-1

Abstract:

Procollagen C-proteinase enhancer-1 (PCPE-1) is a secreted protein that specifically accelerates proteolytic release of the C-propeptides from fibrillar procollagens, a crucial step in fibril assembly. As such, it is a potential therapeutic target to improve tissue repair and prevent fibrosis, a major cause of mortality worldwide. Here we present the crystal structure of the active CUB1CUB2 fragment of PCPE-1 bound to the C-propeptide trimer of procollagen III (CPIII). This shows that the two...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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Role:
Author
ORCID:
0000-0002-5967-2552
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Name:
Biotechnology and Biological Sciences Research Council
Grant:
BB/D524840/1
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Name:
Wellcome Trust
Grant:
202926/Z/16/Z
Publisher:
Elsevier
Journal:
Structure More from this journal
Volume:
26
Issue:
10
Pages:
1384-1392.e3
Publication date:
2018-08-02
Acceptance date:
2018-06-28
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
Pmid:
30078642
Language:
English
Keywords:
Pubs id:
pubs:934929
UUID:
uuid:fbd23859-e6ee-4356-8f10-91da7a2400c6
Local pid:
pubs:934929
Source identifiers:
934929
Deposit date:
2019-07-17

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