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Hyaluronan derived from the limbus is a key regulator of corneal lymphangiogenesis

Abstract:
Purpose: We recently reported that the glycosaminoglycan hyaluronan (HA), which promotes inflammatory angiogenesis in other vascular beds, is an abundant component of the limbal extracellular matrix. Consequently, we have explored the possibility that HA contributes to lymphangiogenesis in the inflamed cornea.

Methods: To study the role of HA on lymphangiogenesis, we used mice lacking the hyaluronan synthases and injury models that induce lymphangi... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1167/iovs.18-25920

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Publisher:
Association for Research in Vision and Ophthalmology Publisher's website
Journal:
Investigative Ophthalmology and Visual Science Journal website
Volume:
60
Issue:
4
Publication date:
2019-03-01
Acceptance date:
2019-02-12
DOI:
EISSN:
1552-5783
ISSN:
0146-0404
Pubs id:
pubs:985758
URN:
uri:fbc4d845-19db-49b5-86bc-b4d5c40c0a1e
UUID:
uuid:fbc4d845-19db-49b5-86bc-b4d5c40c0a1e
Local pid:
pubs:985758

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