Journal article
The effect of the 5-HT4 agonist, Prucalopride, on a functional magnetic resonance imaging faces task in the healthy human brain
- Abstract:
- Depression is a common and often recurrent illness with significant negative impact on a global scale. Current antidepressants are ineffective for up to one third of people with depression, many of whom experience persistent symptomatology. 5-HT4 receptor agonists show promise in both animal models of depression and cognitive deficit. We therefore studied the effect of the 5-HT4 partial agonist prucalopride (1 mg daily for 6 days) on the neural processing of emotional faces in 43 healthy participants using a randomised placebo-controlled design. Participants receiving prucalopride were more accurate at identifying the gender of emotional faces. In whole brain analyses, prucalopride was also associated with reduced activation in a network of regions corresponding to the default mode network. However, there was no evidence that prucalopride treatment produced a positive bias in the neural processing of emotional faces. Our study provides further support for a pro-cognitive effect of 5-HT4 receptor agonism in humans. While our current behavioural and neural investigations do not suggest an antidepressant-like profile of prucalopride in humans, it will be important to study a wider dose range in future studies.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 3.2MB, Terms of use)
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- Publisher copy:
- 10.3389/fpsyt.2022.859123
Authors
- Publisher:
- Frontiers Media
- Journal:
- Frontiers in Psychiatry More from this journal
- Volume:
- 13
- Article number:
- 859123
- Publication date:
- 2022-04-12
- Acceptance date:
- 2022-02-22
- DOI:
- EISSN:
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1664-0640
- Language:
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English
- Keywords:
- Pubs id:
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1250300
- Local pid:
-
pubs:1250300
- Deposit date:
-
2022-04-15
Terms of use
- Copyright holder:
- de Cates et al
- Copyright date:
- 2022
- Rights statement:
- © 2022 de Cates, Martens, Wright, Gould van Praag, Capitão, Gibson, Cowen, Harmer and Murphy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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