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Journal article

The chromatin remodeller ATRX: a repeat offender in human disease.

Abstract:

The regulation of chromatin structure is of paramount importance for a variety of fundamental nuclear processes, including gene expression, DNA repair, replication, and recombination. The ATP-dependent chromatin-remodelling factor ATRX (α thalassaemia/mental retardation X-linked) has emerged as a key player in each of these processes. Exciting recent developments suggest that ATRX plays a variety of key roles at tandem repeat sequences within the genome, including the deposition of a histone ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.tibs.2013.06.011

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Clinical Laboratory Sciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Strategic
Medical Research Council More from this funder
University of Oxford More from this funder
Publisher:
Cell Press Publisher's website
Journal:
Trends in biochemical sciences Journal website
Volume:
38
Issue:
9
Pages:
461-466
Publication date:
2013-09-05
DOI:
ISSN:
0968-0004
URN:
uuid:fbad0efa-9fb0-4fcb-af9b-ceaa5466077b
Source identifiers:
416698
Local pid:
pubs:416698

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