Journal article
The early youth engagement (EYE-2) intervention in first-episode psychosis services: pragmatic cluster randomised controlled trial and cost-effectiveness evaluation
- Abstract:
-
Background: Early intervention in psychosis (EIP) services improve outcomes for young people, but approximately 30% disengage.
Aims: To test whether a new motivational engagement intervention would prolong engagement and whether it was cost-effective.
Method: We conducted a multicentre, single-blind, parallel-group, cluster randomised controlled trial involving 20 EIP teams at five UK National Health Service (NHS) sites. Teams were randomised using permuted blocks stratified by NHS trust. Participants were all young people (aged 14–35 years) presenting with a first episode of psychosis between May 2019 and July 2020 (N = 1027). We compared the novel Early Youth Engagement (EYE-2) intervention plus standardised EIP (sEIP) with sEIP alone. The primary outcome was time to disengagement over 12–26 months. Economic outcomes were mental health costs, societal costs and socio-occupational outcomes over 12 months. Assessors were masked to treatment allocation for primary disengagement and cost-effectiveness outcomes. Analysis followed intention-to-treat principles. The trial was registered at ISRCTN51629746.
Results: Disengagement was low at 15.9% overall in standardised stand-alone services. The adjusted hazard ratio for EYE-2 + sEIP (n = 652) versus sEIP alone (n = 375) was 1.07 (95% CI 0.76–1.49; P = 0.713). The health economic evaluation indicated lower mental healthcare costs linked to reductions in unplanned mental healthcare with no compromise of clinical outcomes, as well as some evidence for lower societal costs and more days in education, training, employment and stable accommodation in the EYE-2 group.
Conclusions: We found no evidence that EYE-2 increased time to disengagement, but there was some evidence for its cost-effectiveness. This is the largest study to date reporting positive engagement, health and cost outcomes in a total EIP population sample. Limitations included high loss to follow-up for secondary outcomes and low completion of societal and socio-occupational data. COVID-19 affected fidelity and implementation. Future engagement research should target engagement to those in greatest need, including in-patients and those with socio-occupational goals.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 587.4KB, Terms of use)
-
- Publisher copy:
- 10.1192/bjp.2024.154
Authors
- Publisher:
- Cambridge University Press
- Journal:
- British Journal of Psychiatry More from this journal
- Volume:
- 226
- Issue:
- 3
- Pages:
- 144-152
- Publication date:
- 2024-11-25
- Acceptance date:
- 2024-07-30
- DOI:
- EISSN:
-
1472-1465
- ISSN:
-
0007-1250
- Pmid:
-
39581220
- Language:
-
English
- Keywords:
- Pubs id:
-
2066920
- Local pid:
-
pubs:2066920
- Deposit date:
-
2025-02-01
- ARK identifier:
Terms of use
- Copyright holder:
- Greenwood et al.
- Copyright date:
- 2024
- Rights statement:
- © The Author(s), 2024. Published by Cambridge University Press on behalf of Royal College of Psychiatrists. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record