Nerve damage induced by mycobacterial granulomas in guinea pig sciatic nerves.

Cowley, SA; Butter, C; Verghese, S; Curtis, J; Turk, JL

Abstract:

A possible model for nerve damage in leprosy has been developed in the sciatic nerve of the guinea pig. Intraneural injection of 10(7) BCG organisms into an unsensitized animal induces an epithelioid cell granuloma in 2 weeks similar to that found in tuberculoid leprosy patients. In contrast, intraneural injection of 10(9) cobalt-irradiated Mycobacterium leprae organisms induces a macrophage granuloma in 5 weeks, similar to that found in lepromatous leprosy patients. Histological, immunohisto...

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APA Style

Cowley, S. A., Butter, C., Verghese, S., Curtis, J., & Turk, J. L. (1988). Nerve damage induced by mycobacterial granulomas in guinea pig sciatic nerves. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 56(2), 283–290.

MLA Style

Cowley, S. A., et al. “Nerve Damage Induced by Mycobacterial Granulomas in Guinea Pig Sciatic Nerves.” International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 56, no. 2, International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1988, pp. 283–90.

Chicago Style

Cowley, SA, C Butter, S Verghese, J Curtis, and JL Turk. 1988. “Nerve Damage Induced by Mycobacterial Granulomas in Guinea Pig Sciatic Nerves.” International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association 56 (2): 283–90.
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Authors

+ Cowley, SA More by this author

Institution:

University of Oxford

Department:

Oxford, MSD, Pathology Dunn School

Butter, C More by this author

Verghese, S More by this author

Curtis, J More by this author

Turk, JL More by this author

Bibliographic Details

Journal:: International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
Volume:: 56
Issue:: 2
Pages:: 283-290
Publication date:: 1988-06-05
EISSN:: 1544-581X
ISSN:: 0148-916X
URN:: uuid:fba75107-76b1-433d-8dc5-c5c1061a7fee
Source identifiers:: 223739
Local pid:: pubs:223739

Item Description

Language:: English
Keywords:: Mycobacterium bovis

Immunohistochemistry

Animals

Female

Peripheral Nervous System Diseases

Microscopy, Electron

Granuloma

Guinea Pigs

Electrophysiology

Mycobacterium leprae

Leprosy

Disease Models, Animal

Sciatic Nerve

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