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Nerve damage induced by mycobacterial granulomas in guinea pig sciatic nerves.

Abstract:

A possible model for nerve damage in leprosy has been developed in the sciatic nerve of the guinea pig. Intraneural injection of 10(7) BCG organisms into an unsensitized animal induces an epithelioid cell granuloma in 2 weeks similar to that found in tuberculoid leprosy patients. In contrast, intraneural injection of 10(9) cobalt-irradiated Mycobacterium leprae organisms induces a macrophage granuloma in 5 weeks, similar to that found in lepromatous leprosy patients. Histological, immunohisto...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Verghese, S More by this author
Journal:
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
Volume:
56
Issue:
2
Pages:
283-290
Publication date:
1988-06-05
EISSN:
1544-581X
ISSN:
0148-916X
URN:
uuid:fba75107-76b1-433d-8dc5-c5c1061a7fee
Source identifiers:
223739
Local pid:
pubs:223739

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