Nerve damage induced by mycobacterial granulomas in guinea pig sciatic nerves.

Journal article

A possible model for nerve damage in leprosy has been developed in the sciatic nerve of the guinea pig. Intraneural injection of 10(7) BCG organisms into an unsensitized animal induces an epithelioid cell granuloma in 2 weeks similar to that found in tuberculoid leprosy patients. In contrast, intraneural injection of 10(9) cobalt-irradiated Mycobacterium leprae organisms induces a macrophage granuloma in 5 weeks, similar to that found in lepromatous leprosy patients. Histological, immunohistochemical, electron microscopical and electrophysiological studies have demonstrated that the lesions induced in the experimental animals show many of the features documented in studies of nerve damage in leprosy patients.

Authors: Cowley, S; Butter, C; Verghese, S; Curtis, J; Turk, J

• Publication status: Published
• Journal: International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
• Volume: 56
• Issue: 2
• Pages: 283-290
• Publication date: 1988-06-01
• EISSN: 1544-581X
• ISSN: 0148-916X
• Language: English
• Keywords: Sciatic Nerve; Disease Models, Animal; Leprosy; Microscopy, Electron; Female; Peripheral Nervous System Diseases; Electrophysiology; Immunohistochemistry; Mycobacterium leprae; Granuloma; Mycobacterium bovis; Animals; Guinea Pigs