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Journal article

Histone recognition and large-scale structural analysis of the human bromodomain family.

Abstract:

Bromodomains (BRDs) are protein interaction modules that specifically recognize ε-N-lysine acetylation motifs, a key event in the reading process of epigenetic marks. The 61 BRDs in the human genome cluster into eight families based on structure/sequence similarity. Here, we present 29 high-resolution crystal structures, covering all BRD families. Comprehensive crossfamily structural analysis identifies conserved and family-specific structural features that are necessary for specific acetylat...

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Publication status:
Published

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Publisher copy:
10.1016/j.cell.2012.02.013

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Role:
Author
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Journal:
Cell
Volume:
149
Issue:
1
Pages:
214-231
Publication date:
2012-03-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:fb9db039-772d-40d9-8e2f-6eeef76e647f
Source identifiers:
322665
Local pid:
pubs:322665

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