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Journal article

The talin-tail interaction places integrin activation on FERM ground.

Abstract:

Integrins are essential receptors for the development and functioning of multicellular animals because they mediate cell migration and cell adhesion, and regulate cell proliferation and apoptosis. Cellular regulation of the affinity of integrins for ligands - so-called 'integrin activation' - is a central property of these receptors. Integrin activation controls cell adhesion, migration and extracellular matrix assembly, thereby contributing to processes such as angiogenesis, tumor cell metas...

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Publisher copy:
10.1016/j.tibs.2004.06.005
Journal:
Trends in biochemical sciences More from this journal
Volume:
29
Issue:
8
Pages:
429-435
Publication date:
2004-08-01
DOI:
ISSN:
0968-0004
Language:
English
Keywords:
Pubs id:
pubs:246510
UUID:
uuid:fb7ffa8f-60bc-4af0-a9d7-55c80f737c56
Local pid:
pubs:246510
Source identifiers:
246510
Deposit date:
2013-11-16

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