Use of methods for specifying the target difference in randomised controlled trial sample size calculations: Two surveys of trialists' practice.
BACKGROUND: Central to the design of a randomised controlled trial (RCT) is a calculation of the number of participants needed. This is typically achieved by specifying a target difference, which enables the trial to identify a difference of a particular magnitude should one exist. Seven methods have been proposed for formally determining what the target difference should be. However, in practice, it may be driven by convenience or some other informal basis. It is unclear how aware the triali...Expand abstract
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Copyright © The Author(s), 2014.
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