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Journal article

Use of methods for specifying the target difference in randomised controlled trial sample size calculations: Two surveys of trialists' practice.

Abstract:

BACKGROUND: Central to the design of a randomised controlled trial (RCT) is a calculation of the number of participants needed. This is typically achieved by specifying a target difference, which enables the trial to identify a difference of a particular magnitude should one exist. Seven methods have been proposed for formally determining what the target difference should be. However, in practice, it may be driven by convenience or some other informal basis. It is unclear how aware the triali...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1177/1740774514521907

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Centre for Statistics in Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Centre for Statistics in Medicine
Role:
Author
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More from this funder
Funding agency for:
Cook, J
Grant:
G0601938
G1002292
Medical Research Council More from this funder
National Institute for Health Research More from this funder
Publisher:
SAGE Publications Publisher's website
Journal:
Clinical trials (London, England) Journal website
Volume:
11
Issue:
3
Pages:
300-308
Publication date:
2014-01-01
DOI:
EISSN:
1740-7753
ISSN:
1740-7745
Source identifiers:
456165
Language:
English
Keywords:
Pubs id:
pubs:456165
UUID:
uuid:fb77a09b-db0f-4ca4-af95-1fbae296ec1e
Local pid:
pubs:456165
Deposit date:
2014-05-13

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