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Journal article

Use of methods for specifying the target difference in randomised controlled trial sample size calculations: Two surveys of trialists' practice.

Abstract:

BACKGROUND: Central to the design of a randomised controlled trial (RCT) is a calculation of the number of participants needed. This is typically achieved by specifying a target difference, which enables the trial to identify a difference of a particular magnitude should one exist. Seven methods have been proposed for formally determining what the target difference should be. However, in practice, it may be driven by convenience or some other informal basis. It is unclear how aware the triali...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1177/1740774514521907

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, CSM
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, CSM
Role:
Author
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Medical Research Council More from this funder
National Institute for Health Research More from this funder
Publisher:
SAGE Publisher's website
Journal:
Clinical trials (London, England) Journal website
Volume:
11
Issue:
3
Pages:
300-308
Publication date:
2014-01-01
DOI:
EISSN:
1740-7753
ISSN:
1740-7745
URN:
uuid:fb77a09b-db0f-4ca4-af95-1fbae296ec1e
Source identifiers:
456165
Local pid:
pubs:456165
Language:
English
Keywords:

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