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The potassium-chloride cotransporter 2 promotes cervical cancer cell migration and invasion by an ion transport-independent mechanism

Abstract:

K +-Cl - cotransporters (KCCs) play a fundamental role in epithelial cell function, both in the context of ionic homeostasis and also in cell morphology, cell division and locomotion. Unlike other ubiquitously expressed KCC isoforms, expression of KCC2 is widely considered to be restricted to neurons, where it is responsible for maintaining a low intracellular chloride concentration to drive hyperpolarising postsynaptic responses to the inhibitory neurotransmitters GABA and glycine. Here we r...

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Clinch, NWV More by this author
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Journal:
Journal of Physiology
Volume:
589
Issue:
22
Pages:
5349-5359
Publication date:
2011-11-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:fb61c15b-d0c0-40d0-9b49-36c393bff381
Source identifiers:
216349
Local pid:
pubs:216349
Language:
English

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