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Journal article

Recurrent gene amplification and soft selective sweeps during evolution of multidrug resistance in malaria parasites.

Abstract:

When selection is strong and beneficial alleles have a single origin, local reductions in genetic diversity are expected. However, when beneficial alleles have multiple origins or were segregating in the population prior to a change in selection regime, the impact on genetic diversity may be less clear. We describe an example of such a "soft" selective sweep in the malaria parasite Plasmodium falciparum that involves adaptive genome rearrangements. Amplification in copy number of genome regio...

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Publication status:
Published

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Publisher copy:
10.1093/molbev/msl185

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Journal:
Molecular biology and evolution
Volume:
24
Issue:
2
Pages:
562-573
Publication date:
2007-02-05
DOI:
EISSN:
1537-1719
ISSN:
0737-4038
URN:
uuid:fb574c07-adc7-4ac4-bfc8-cb1a0aeb02eb
Source identifiers:
18967
Local pid:
pubs:18967

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