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IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria.

Abstract:

Interferon (IFN)-gamma is a critical mediator of immunity to malaria. This study explored the relationship between polymorphisms in the promoter region of the gene encoding IFN-gamma receptor 1 (IFNGR1) and susceptibility to malaria in African children. Four polymorphisms were found in the region between -1400 and +100 nt of the translational start site by sequencing, and analysis of 562 nuclear families revealed 6 haplotypes. Case-control analysis of 562 Gambian children with severe malaria ...

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Publication status:
Published

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Publisher copy:
10.1086/340516

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Journal:
Journal of infectious diseases More from this journal
Volume:
185
Issue:
11
Pages:
1684-1687
Publication date:
2002-06-01
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Language:
English
Keywords:
Pubs id:
pubs:133544
UUID:
uuid:fb4ffb25-2164-43d6-8c10-1d18503badc8
Local pid:
pubs:133544
Source identifiers:
133544
Deposit date:
2013-11-16

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