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The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs

Abstract:

RNA-binding proteins (RBPs) exert a broad range of biological functions. To explore the scope of RBPs across eukaryotic evolution, we determined the in vivo RBP repertoire of the yeast Saccharomyces cerevisiae and identified 678 RBPs from yeast and additionally 729 RBPs from human hepatocytic HuH-7 cells. Combined analyses of these and recently published data sets define the core RBP repertoire conserved from yeast to man. Conserved RBPs harbour defined repetitive motifs within disordered reg...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms10127

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More from this funder
Name:
German Ministry for Education and Research
Funding agency for:
Hentze, M
Grant:
Advanced Grant
More from this funder
Name:
European Research Council
Funding agency for:
Hentze, M
Grant:
Advanced Grant
More from this funder
Name:
Marie Curie Fellowship
Funding agency for:
Beckmann, B
Grant:
FP7/2007-2013/MC-IEF-301031
Publisher:
Nature Publishing Group
Journal:
Nature Communications More from this journal
Volume:
6
Publication date:
2015-12-03
Acceptance date:
2015-11-05
DOI:
EISSN:
2041-1723
Pubs id:
pubs:625720
UUID:
uuid:fb2c62a8-f3b7-4570-8797-f6034a67d29d
Local pid:
pubs:625720
Source identifiers:
625720
Deposit date:
2016-06-06

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