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CTLs respond with activation and granule secretion when serving as targets for T-cell recognition.

Abstract:

Cytotoxic T lymphocytes (CTLs) suppress T cell responses directed against their antigens regardless of their own T cell receptor (TCR) specificity. This makes the use of CTLs promising for tolerance induction in autoimmunity and transplantation. It has been established that binding of the CTL CD8 molecule to the major histocompatibility complex (MHC) class I α3 domain of the recognizing T cell must be permitted for death of the latter cell to ensue. However, the signaling events triggered in ...

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Journal:
Blood
Volume:
117
Issue:
3
Pages:
1042-1052
Publication date:
2011-01-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:fb27e946-4940-45fc-ae31-9e00901a96bf
Source identifiers:
426275
Local pid:
pubs:426275

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