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Leukaemia lineage specification caused by cell-specific Mll-Enl translocations.

Abstract:

Chromosomal translocations involving the Mixed-Lineage Leukaemia (MLL) gene underlie many human leukaemias and MLL rearrangements are found in both acute myelogenous and acute lymphoblastic leukaemias. To assess the functionally relevant haematopoietic cell contexts for MLL fusions to be tumorigenic, we have generated different lines of mice in which de novo Mll-associated translocations occur. In these models, reciprocal chromosomal translocations occur by means of Cre-loxP-mediated recombin...

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Publisher copy:
10.1038/sj.onc.1210818

Authors


Drynan, LF More by this author
Pannell, R More by this author
Rabbitts, TH More by this author
Journal:
Oncogene
Volume:
27
Issue:
13
Pages:
1945-1950
Publication date:
2008-03-05
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:fb163248-271d-4297-80fe-909aae9f356f
Source identifiers:
324260
Local pid:
pubs:324260

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