Journal article icon

Journal article

Profound defects in pupillary responses to light in TRPM-channel null mice: a role for TRPM channels in non-image-forming photoreception.

Abstract:

TRPM1 is a spontaneously active non-selective cation channel that has recently been shown to play an important role in the depolarizing light responses of ON bipolar cells. Consistent with this role, mutations in the TRPM1 gene have been identified as a principal cause of congenital stationary night blindness. However, previous microarray studies have shown that Trpm1 and Trpm3 are acutely regulated by light in the eyes of mice lacking rods and cones (rd/rd cl), a finding consistent with a ro...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Pothecary, CA More by this author
Jagannath, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Expand authors...
Journal:
The European journal of neuroscience
Volume:
35
Issue:
1
Pages:
34-43
Publication date:
2012-01-05
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
URN:
uuid:fb14a6df-5c60-4180-a510-7d499cf1a2db
Source identifiers:
222363
Local pid:
pubs:222363

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP