- Abstract:
-
Understanding the underlying molecular basis for disease can often be a prolonged and tortuous process with many false leads and blind alleys. Relating the cause of ATR-X syndrome to the function of the protein ATRX is a case in point. In this review we attempt to bring together the diverse biological phenomena associated with ATRX dysfunction with what has recently been discovered concerning the chromatin remodelling activity of this protein. This potentially casts light on how defective DNA...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Files:
-
-
(pdf, 483.2KB)
-
- Publisher copy:
- 10.1016/j.gde.2013.01.005
-
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- Publisher:
- Elsevier Publisher's website
- Journal:
- Current opinion in genetics and development Journal website
- Volume:
- 23
- Issue:
- 3
- Pages:
- 289-294
- Publication date:
- 2013-06-05
- DOI:
- EISSN:
-
1879-0380
- ISSN:
-
0959-437X
- URN:
-
uuid:fb020e95-e0a7-4949-81ff-e39ff98f2010
- Source identifiers:
-
387871
- Local pid:
- pubs:387871
- Copyright holder:
- Elsevier Ltd
- Copyright date:
- 2013
- Notes:
- © 2013 Elsevier Ltd. All rights reserved.
Journal article
ATRX and the replication of structured DNA.
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Medical Research Council
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University of Oxford
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