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The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis.

Abstract:

BACKGROUND: To investigate small-nucleolar RNAs (snoRNAs) as reference genes when measuring miRNA expression in tumour samples, given emerging evidence for their role in cancer. METHODS: Four snoRNAs, commonly used for normalisation, RNU44, RNU48, RNU43 and RNU6B, and miRNA known to be associated with pathological factors, were measured by real-time polymerase chain reaction in two patient series: 219 breast cancer and 46 head and neck squamous cell carcinoma (HNSCC). SnoRNA and miRNA were t...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjc.6606076

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Journal:
British journal of cancer More from this journal
Volume:
104
Issue:
7
Pages:
1168-1177
Publication date:
2011-03-01
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Language:
English
Keywords:
Pubs id:
pubs:124370
UUID:
uuid:faeb0962-5a89-48ee-82fd-cc800c331dec
Local pid:
pubs:124370
Source identifiers:
124370
Deposit date:
2012-12-19

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