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Journal article

Infection, inflammation and intervention: Mechanistic modelling of epithelial cells in COVID-19

Abstract:

While the pathological mechanisms in COVID-19 illness are still poorly understood, it is increasingly clear that high levels of pro-inflammatory mediators play a major role in clinical deterioration in patients with severe disease. Current evidence points to a hyperinflammatory state as the driver of respiratory compromise in severe COVID-19 disease, with a clinical trajectory resembling acute respiratory distress syndrome, but how this ‘runaway train’ inflammatory response emerges and is mai...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1098/rsif.2020.0950

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Oxford college:
Keble College
Role:
Author
ORCID:
0000-0003-1771-5910
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
ORCID:
0000-0002-9993-2478
Publisher:
Royal Society
Journal:
Journal of the Royal Society, Inferface More from this journal
Volume:
18
Issue:
175
Article number:
20200950
Publication date:
2021-02-17
Acceptance date:
2020-11-24
DOI:
EISSN:
1742-5662
ISSN:
1742-5689
Language:
English
Keywords:
Pubs id:
1162194
Local pid:
pubs:1162194
Deposit date:
2021-02-27

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