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Self-assembly and evolution of homomeric protein complexes.

Abstract:

We introduce a simple "patchy particle" model to study the thermodynamics and dynamics of self-assembly of homomeric protein complexes. Our calculations allow us to rationalize recent results for dihedral complexes. Namely, why evolution of such complexes naturally takes the system into a region of interaction space where (i) the evolutionarily newer interactions are weaker, (ii) subcomplexes involving the stronger interactions are observed to be thermodynamically stable on destabilization of...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1103/physrevlett.102.118106

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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Physical and Theoretical Chem
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Publisher:
American Physical Society Publisher's website
Journal:
Physical Review Letters Journal website
Volume:
102
Issue:
11
Pages:
Article: 118106
Publication date:
2009-03-05
DOI:
EISSN:
1079-7114
ISSN:
0031-9007
URN:
uuid:facf86d2-3e98-4f5f-9312-68d2b88851fb
Source identifiers:
12121
Local pid:
pubs:12121

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