Journal article
Self-assembly and evolution of homomeric protein complexes.
- Abstract:
- We introduce a simple "patchy particle" model to study the thermodynamics and dynamics of self-assembly of homomeric protein complexes. Our calculations allow us to rationalize recent results for dihedral complexes. Namely, why evolution of such complexes naturally takes the system into a region of interaction space where (i) the evolutionarily newer interactions are weaker, (ii) subcomplexes involving the stronger interactions are observed to be thermodynamically stable on destabilization of the protein-protein interactions, and (iii) the self-assembly dynamics are hierarchical with these same subcomplexes acting as kinetic intermediates.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 695.1KB, Terms of use)
-
- Publisher copy:
- 10.1103/physrevlett.102.118106
Authors
- Publisher:
- American Physical Society
- Journal:
- Physical Review Letters More from this journal
- Volume:
- 102
- Issue:
- 11
- Article number:
- 118106
- Publication date:
- 2009-03-01
- DOI:
- EISSN:
-
1079-7114
- ISSN:
-
0031-9007
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:12121
- UUID:
-
uuid:facf86d2-3e98-4f5f-9312-68d2b88851fb
- Local pid:
-
pubs:12121
- Source identifiers:
-
12121
- Deposit date:
-
2013-03-20
Terms of use
- Copyright holder:
- American Physical Society
- Copyright date:
- 2009
- Notes:
- Gabriel Villar, Alex W. Wilber, Alex J. Williamson, Parvinder Thiara, Jonathan P. K. Doye, Ard A. Louis, Mara N. Jochum, Anna C. F. Lewis, and Emmanuel D. Levy. Physical Review Letters - Moving physics forward; v.102:issue.11, 118106 (2009). Copyright 2009 American Physical Society.
If you are the owner of this record, you can report an update to it here: Report update to this record