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Value of Plasmodium falciparum histidine-rich protein 2 level and malaria retinopathy in distinguishing cerebral malaria from other acute encephalopathies in Kenyan children.

Abstract:

BACKGROUND: The diagnosis of cerebral malaria is problematic in malaria-endemic areas because encephalopathy in patients with parasitemia may have another cause. Abnormal retinal findings are thought to increase the specificity of the diagnosis, and the level of histidine-rich protein 2 (HRP2) may reflect the parasite biomass. METHODS: We examined the retina and measured plasma HRP2 levels in children with acute nontraumatic encephalopathy in Kenya. Logistic regression, with HRP2 level as an ...

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Publication status:
Published

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Publisher copy:
10.1093/infdis/jit500

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Journal:
The Journal of infectious diseases
Volume:
209
Issue:
4
Pages:
600-609
Publication date:
2014-02-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:faafea03-02b2-488e-a915-8e11efad4eb6
Source identifiers:
429343
Local pid:
pubs:429343

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