Kaposi's sarcoma-associated herpesvirus and Kaposi's sarcoma in Africa. Uganda Kaposi's Sarcoma Study Group.

Chang, Y; Ziegler, J; Wabinga, H; Katangole-Mbidde, E; Boshoff, C; Schulz, T; Whitby, D; Maddalena, D; Jaffe, H; Weiss, R; Moore, P

Journal article

Kaposi's sarcoma-associated herpesvirus and Kaposi's sarcoma in Africa. Uganda Kaposi's Sarcoma Study Group.

Abstract:: BACKGROUND: Endemic Kaposi's sarcoma (KS) is a clinically and epidemiologically distinct human immunodeficiency virus negative form of KS occurring in Africa. Kaposi's sarcoma is now the most frequently reported cancer in some areas of Africa. OBJECTIVE: To determine if a KS-associated herpesvirus (KSHV) is present in both endemic HIV-seronegative and HIV-seropositive KS lesions from African patients. METHODS: Paraffin-embedded tissue specimens from Ugandan patients with KS and non-KS tumor control patients attending a university-based oncology clinic were examined in a blinded case-control study. Tissue DNA specimens were examined for detectable KSHV genome by nested polymerase chain reaction performed at two independent laboratories. RESULTS: We identified KSHV in 17 (85%) of 20 KS tissue specimens from HIV-seronegative patients and 22 (92%) of 24 KS tissue specimens from HIV-infected persons. Kaposi's sarcoma lesions from four HIV-infected persons and four HIV-seronegative persons were positive for KSHV. Unlike previous studies in North America and Europe, three (14%) of 22 non-KS cancer control patients' tissue specimens were also positive for KSHV that resulted in an overall odds ratio of 49.2 (95% confidence interval, 9.1 to 335) for detecting KSHV in KS lesions from patients in Uganda. CONCLUSION: As in North America and Europe, KSHV infection is strongly associated with both HIV-seropositive and HIV-seronegative KS in Africa. However, it is likely that infection with this virus is more highly prevalent in Uganda.

Publication status:: Published

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APA Style

Chang, Y., Ziegler, J., Wabinga, H., Katangole-Mbidde, E., Boshoff, C., Schulz, T., Whitby, D., Maddalena, D., Jaffe, H., Weiss, R., & Moore, P. (1996). Kaposi's sarcoma-associated herpesvirus and Kaposi's sarcoma in Africa. Uganda Kaposi's Sarcoma Study Group. Archives of Internal Medicine, 156(2), 202–204.

MLA Style

Chang, Y, et al. “Kaposi's Sarcoma-Associated Herpesvirus and Kaposi's Sarcoma in Africa. Uganda Kaposi's Sarcoma Study Group.” Archives of Internal Medicine, vol. 156, no. 2, 1996, pp. 202–04.

Chicago Style

Chang, Y, J Ziegler, H Wabinga, et al. 1996. “Kaposi's Sarcoma-Associated Herpesvirus and Kaposi's Sarcoma in Africa. Uganda Kaposi's Sarcoma Study Group.” Archives of Internal Medicine 156 (2): 202–4.
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