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Nutritional control of cell size by the Greatwall-endosulfine-PP2A·B55 pathway

Abstract:

Proliferating cells adjust their cell size depending on the nutritional environment. Cells are large in rich media and small in poor media. This physiological response has been demonstrated in both unicellular and multicellular organisms. Here we show that the greatwall-endosulfine (Ppk18-Igo1 in fission yeast) pathway couples the nutritional environment to the cell-cycle machinery by regulating the activity of PP2A·B55. In the presence of nutrients, greatwall (Ppk18) protein kinase is inhibi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.cub.2015.12.035

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More from this funder
Name:
Biotechnology and Biological Sciences Research Council
Grant:
BB/MM00354X/1
More from this funder
Name:
EC 7th Framework Program
Grant:
MitoSys-241548
More from this funder
Name:
Junta de Castilla y León
Grant:
CSI151U13
More from this funder
Name:
Spanish Ministry of Economy and Competitiveness
Grant:
BFU2014-55439
Publisher:
Elsevier
Journal:
Current Biology More from this journal
Volume:
26
Issue:
3
Pages:
319-330
Publication date:
2016-01-14
Acceptance date:
2015-12-09
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
Language:
English
Keywords:
Pubs id:
pubs:598033
UUID:
uuid:fa98b4ee-18a4-43a0-84f3-c3c8b75abec3
Local pid:
pubs:598033
Source identifiers:
598033
Deposit date:
2016-01-28

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