Journal article

Assessing clinical and cost effectiveness of total versus partial knee replacement (TOPKAT): 10-year follow-up of a multicentre, randomised controlled trial

Abstract:: Background
The Total or Partial Knee Arthroplasty Trial (TOPKAT) aimed to evaluate the difference between total knee replacement (TKR) and partial (unicompartmental) replacement (PKR) for treatment of late-stage medial compartment knee osteoarthritis. As longevity is a key issue for joint replacement, extended follow-up periods are required to fully evaluate the long-term efficacy. In this analysis, we report the 10-year follow-up of the TOPKAT trial.
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Beard, D., Davies, L. J., Cook, J. A., MacLennan, G., Hudson, J., Price, A., Carr, A., Little, M., Leal, J., Fitzpatrick, R., Murray, D. W., & Campbell, M. K. (2025). Assessing clinical and cost effectiveness of total versus partial knee replacement (TOPKAT): 10-year follow-up of a multicentre, randomised controlled trial. Lancet Rheumatology, 8(2), e116–e126.

MLA Style

Beard, D, et al. “Assessing Clinical and Cost Effectiveness of Total versus Partial Knee Replacement (TOPKAT): 10-Year Follow-up of a Multicentre, Randomised Controlled Trial.” Lancet Rheumatology, vol. 8, no. 2, 2025, pp. e116–e126.

Chicago Style

Beard, D, LJ Davies, JA Cook, et al. 2025. “Assessing Clinical and Cost Effectiveness of Total versus Partial Knee Replacement (TOPKAT): 10-Year Follow-up of a Multicentre, Randomised Controlled Trial.” Lancet Rheumatology 8 (2): e116–e126.
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Files:: Beard_et_al_2025_Assessing_clinical_and.pdf

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Publisher copy:: 10.1016/S2665-9913(25)00250-4

Authors

+ Beard, D More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDORMS
Sub department:: Botnar Institute for Musculoskeletal Sciences
Oxford college:: Kellogg College
Role:: Author
ORCID:: 0000-0001-7884-6389

+ Davies, LJ More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDORMS
Sub department:: Botnar Institute for Musculoskeletal Sciences
Role:: Author

+ Cook, JA More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDORMS
Sub department:: Botnar Institute for Musculoskeletal Sciences
Role:: Author
ORCID:: 0000-0002-4156-6989

+ MacLennan, G More by this author

Role:: Author

+ Hudson, J More by this author

Role:: Author

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Contributors

+ TOPKAT Study Group

Role:: Contributor

+ NIHR Evaluation Trials and Studies Coordinating Centre More from this funder

Funder identifier:: https://ror.org/03d7d0579
Grant:: 08/14/08

Publisher:: Elsevier
Journal:: Lancet Rheumatology More from this journal
Volume:: 8
Issue:: 2
Pages:: e116-e126
Publication date:: 2025-11-18
Acceptance date:: 2025-08-18
DOI:: 10.1016/S2665-9913(25)00250-4
EISSN:: 2665-9913

Language:: English
Pubs id:: 2284306
Local pid:: pubs:2284306
Deposit date:: 2025-09-17
ARK identifier:: ark:/29072/ora_fa986c2ceae04b9f8e73bcb866f8682b

Terms of use

Copyright holder:: Beard et al
Copyright date:: 2025
Rights statement:: © 2025 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.

Licence:: CC Attribution (CC BY)

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