Journal article

One-pot catalytic enantioselective synthesis of tetrahydropyridines via a nitro-Mannich/hydroamination cascade.

Abstract:: The highly enantioselective preparation of synthetically useful tetrahydropyridine derivatives employing a one-pot nitro-Mannich/hydroamination cascade is reported. This approach utilizes an asymmetric organocatalytic nitro-Mannich reaction followed by a gold-catalyzed alkyne hydroamination/isomerization sequence that yields the desired tetrahydropyridines in good yields and high diastereo- and enantioselectivities.

Publication status:: Published

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APA Style

Barber, D., Sanganee, H., & Dixon, D. (2012). One-pot catalytic enantioselective synthesis of tetrahydropyridines via a nitro-Mannich/hydroamination cascade. Organic Letters, 14(20), 5290–5293.

MLA Style

Barber, D., et al. “One-Pot Catalytic Enantioselective Synthesis of Tetrahydropyridines via a Nitro-Mannich/Hydroamination Cascade.” Organic Letters, vol. 14, no. 20, 2012, pp. 5290–93.

Chicago Style

Barber, D, H Sanganee, and D Dixon. 2012. “One-Pot Catalytic Enantioselective Synthesis of Tetrahydropyridines via a Nitro-Mannich/Hydroamination Cascade.” Organic Letters 14 (20): 5290–93.
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Publisher copy:: 10.1021/ol302459c

Authors

+ Barber, D More by this author

Role:: Author

+ Sanganee, H More by this author

Role:: Author

+ Dixon, D More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

Journal:: Organic letters More from this journal
Volume:: 14
Issue:: 20
Pages:: 5290-5293
Publication date:: 2012-10-05
DOI:: 10.1021/ol302459c
EISSN:: 1523-7052
ISSN:: 1523-7060

Language:: English
Keywords:: Hydrogenation

Molecular Structure

Pyridines

Nitro Compounds

Catalysis

Stereoisomerism

Amination
Pubs id:: pubs:353943
UUID:: uuid:fa90a717-ba5b-4965-a010-75466e5abfbe
Local pid:: pubs:353943
Source identifiers:: 353943
Deposit date:: 2013-11-17

Terms of use

Copyright date:: 2012

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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