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Journal article

Rheumatoid synovial fibroblasts differentiate into distinct subsets in the presence of cytokines and cartilage

Abstract:

Background

We investigated two distinct synovial fibroblast populations that were located preferentially in the lining or sub-lining layers and defined by their expression of either podoplanin (PDPN) or CD248, and explored their ability to undergo self-assembly and transmigration in vivo.

Methods

Synovial fibroblasts (SF) were cultured in vitro and phenotypic changes following stimulation with interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and transforming gr...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


More from this funder
Name:
Wellcome Trust
Grant:
WT104551MA
WT104551MA
More from this funder
Name:
Arthritis Research UK
Grant:
18547
20298
Publisher:
BioMed Central
Journal:
Arthritis Research and Therapy More from this journal
Volume:
18
Issue:
1
Pages:
270
Publication date:
2016-11-18
Acceptance date:
2016-10-19
DOI:
EISSN:
1478-6362
ISSN:
1478-6354
Pubs id:
pubs:727905
UUID:
uuid:fa8ad3a3-79fe-4623-8323-4bb04ce107d7
Local pid:
pubs:727905
Source identifiers:
727905
Deposit date:
2018-05-15

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