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Nerve growth factor receptor mRNA distribution in human brain: normal levels in basal forebrain in Alzheimer's disease.

Abstract:

Nerve growth factor (NGF) receptor mRNA was found to be widely distributed throughout the human central nervous system, with the highest levels in the basal forebrain; this suggests that NGF may function as a retrograde trophic messenger for basal forebrain magnocellular cholinergic nerve cells. The degeneration of the latter constitutes one of the main features of Alzheimer's disease and it may be responsible for some of the cognitive impairment that characterizes the disease. No evidence wa...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Brain research. Molecular brain research
Volume:
5
Issue:
1
Pages:
1-7
Publication date:
1989-01-01
DOI:
ISSN:
0169-328X
Source identifiers:
35186
Language:
English
Keywords:
Pubs id:
pubs:35186
UUID:
uuid:fa80fd27-c565-4975-b66f-7ed00c6bfd7f
Local pid:
pubs:35186
Deposit date:
2012-12-19

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