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Nerve growth factor receptor mRNA distribution in human brain: normal levels in basal forebrain in Alzheimer's disease.

Abstract:

Nerve growth factor (NGF) receptor mRNA was found to be widely distributed throughout the human central nervous system, with the highest levels in the basal forebrain; this suggests that NGF may function as a retrograde trophic messenger for basal forebrain magnocellular cholinergic nerve cells. The degeneration of the latter constitutes one of the main features of Alzheimer's disease and it may be responsible for some of the cognitive impairment that characterizes the disease. No evidence wa...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
Brain research. Molecular brain research
Volume:
5
Issue:
1
Pages:
1-7
Publication date:
1989-01-05
DOI:
ISSN:
0169-328X
URN:
uuid:fa80fd27-c565-4975-b66f-7ed00c6bfd7f
Source identifiers:
35186
Local pid:
pubs:35186

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