The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of heritability. To test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole genome sequencing...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
- Accepted manuscript
- ENGAGE: HEALTH-F4-2007-201413; Marie-Curie Fellowship PIEF-GA-2012-329156
- Copyright holder:
- Fuchsberger et al.
- Copyright date:
Author(s) retain copyright; published by Nature Publishing Group under license. A full list of authors and funding information is available in the article.
This is the accepted manuscript version of the article. The final version is available online from Nature at: [10.1038/nature18642]
The genetic architecture of type 2 diabetes
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record