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The genetic architecture of type 2 diabetes

Abstract:

The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of heritability. To test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole genome sequencing...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/nature18642

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Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Role:
Author
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Grant:
ENGAGE: HEALTH-F4-2007-201413; Marie-Curie Fellowship PIEF-GA-2012-329156
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Grant:
G0601261, G0900747-91070
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Grant:
(RC2-DK088389, DK085545, DK098032)
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Grant:
(064890, 083948, 085475, 086596, 090367, 090532, 092447, 095101, 095552, 098017, 098381, 100956)
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Journal website
Volume:
536
Pages:
41–47
Publication date:
2016-07-11
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:fa74de64-0ca3-450e-a037-d9269f2418b8
Source identifiers:
628233
Local pid:
pubs:628233

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