Journal article
The genetic architecture of type 2 diabetes
- Abstract:
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The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of heritability. To test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole genome sequencing...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
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(Accepted manuscript, pdf, 1.4MB)
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- Publisher copy:
- 10.1038/nature18642
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Authors
Funding
+ European Commission
More from this funder
Grant:
Marie-Curie Fellowship PIEF-GA-2012-329156
ENGAGE: HEALTH-F4-2007-201413
+ Wellcome Trust
More from this funder
Grant:
064890, 083948, 085475, 086596, 090367, 090532, 092447, 095101,
095552, 098017, 098381, 100956
Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Journal website
- Volume:
- 536
- Pages:
- 41–47
- Publication date:
- 2016-07-11
- Acceptance date:
- 2016-06-12
- DOI:
- EISSN:
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1476-4687
- ISSN:
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0028-0836
- Source identifiers:
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628233
Item Description
- Pubs id:
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pubs:628233
- UUID:
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uuid:fa74de64-0ca3-450e-a037-d9269f2418b8
- Local pid:
- pubs:628233
- Deposit date:
- 2016-06-20
Terms of use
- Copyright holder:
- Fuchsberger et al
- Copyright date:
- 2016
- Notes:
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Author(s) retain copyright; published by Nature Publishing Group under license. A full list of authors and funding information is available in the article.
This is the accepted manuscript version of the article. The final version is available online from Nature at: [10.1038/nature18642]
If you are the owner of this record, you can report an update to it here: Report update to this record