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Journal article

Null mutation in human ciliary neurotrophic factor gene confers higher body mass index in males.

Abstract:

Ciliary neurotrophic factor (CNTF) administration reduces weight in leptin-resistant mice via the signalling pathway normally activated by leptin. A G>A null mutation in the CNTF gene results in complete absence of protein. We hypothesised that absence of CNTF could lead to diminished initiation of anorectic pathways, with consequent increase in body mass. In 575 Caucasian men aged 59-73 years, the A/A genotype (frequency 1.9%) was associated with a 10 kg increase in weight (P=0.03, 2 df) ...

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Publication status:
Published

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Publisher copy:
10.1038/sj.ejhg.5200873

Authors


O'Dell, SD More by this author
Syddall, HE More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
European journal of human genetics : EJHG
Volume:
10
Issue:
11
Pages:
749-752
Publication date:
2002-11-05
DOI:
EISSN:
1476-5438
ISSN:
1018-4813
URN:
uuid:fa6bd539-3dc2-4ae7-8671-9d1debac25d6
Source identifiers:
126179
Local pid:
pubs:126179

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