Journal article icon

Journal article

Improved cell-penetrating peptide-PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle.

Abstract:

Steric blocking peptide nucleic acid (PNA) oligonucleotides have been used increasingly for redirecting RNA splicing particularly in therapeutic applications such as Duchenne muscular dystrophy (DMD). Covalent attachment of a cell-penetrating peptide helps to improve cell delivery of PNA. We have used a HeLa pLuc705 cell splicing redirection assay to develop a series of PNA internalization peptides (Pip) conjugated to an 18-mer PNA705 model oligonucleotide with higher activity compared to a P...

Expand abstract

Actions


Access Document


Publisher copy:
10.1093/nar/gkn671

Authors


Ivanova, GD More by this author
Arzumanov, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Expand authors...
Journal:
Nucleic acids research
Volume:
36
Issue:
20
Pages:
6418-6428
Publication date:
2008-11-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:fa6728f3-21f7-4816-9b4c-c6ff98d34e1f
Source identifiers:
115539
Local pid:
pubs:115539

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP