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Mechanical cell-cell communication in fibrous networks: the importance of network geometry

Abstract:

Cells contracting in extracellular matrix (ECM) can transmit stress over long distances, communicating their position and orientation to cells many tens of micrometres away. Such phenomena are not observed when cells are seeded on substrates with linear elastic properties, such as polyacrylamide (PA) gel. The ability for fibrous substrates to support far reaching stress and strain fields has implications for many physiological processes, while the mechanical properties of ECM are central to s...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s11538-016-0242-5

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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
Brasenose College
Role:
Author
More from this funder
Name:
Engineering and Physical Sciences Research Council
Funding agency for:
Gaffney, E
Grant:
EP/G03706X/1
More from this funder
Name:
European Research Council
Funding agency for:
Grogan, J
Grant:
FP7/2007-2013) No. 600841 Computational Horizons in Cancer
Publisher:
Springer Verlag
Journal:
Bulletin of Mathematical Biology More from this journal
Publication date:
2017-01-27
Acceptance date:
2016-12-13
DOI:
EISSN:
1522-9602
ISSN:
0092-8240
Keywords:
Pubs id:
pubs:666081
UUID:
uuid:fa61d21e-3256-429f-8ab1-d6f9f1c5fb89
Local pid:
pubs:666081
Source identifiers:
666081
Deposit date:
2016-12-15

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