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Restricted diffusion of a freely diffusible second messenger: mechanisms underlying compartmentalized cAMP signalling.

Abstract:

It is becoming increasingly evident that the freely diffusible second messenger cAMP can transduce specific responses by localized signalling. The machinery that underpins compartmentalized cAMP signalling is only now becoming appreciated. Adenylate cyclases, the enzymes that synthesize cAMP, are localized at discrete parts of the plasma membrane, and phosphodiesterases, the enzymes that degrade cAMP, can be targeted to selected subcellular compartments. A-kinase-anchoring proteins then serve...

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Publisher copy:
10.1042/bst0340510

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Di Benedetto, G More by this author
Lissandron, V More by this author
Mancuso, L More by this author
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Journal:
Biochemical Society transactions
Volume:
34
Issue:
Pt 4
Pages:
495-497
Publication date:
2006-08-05
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
URN:
uuid:fa5863d1-45a7-4b6e-85c9-eb3aefe283b8
Source identifiers:
237861
Local pid:
pubs:237861

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