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Journal article

Hepatitis B virus-like particles expressing Plasmodium falciparum epitopes induce complement-fixing antibodies against the circumsporozoite protein

Abstract:

The repetitive structure of compact virus-like particles (VLPs) provides high density displays of antigenic sequences, which trigger key parts of the immune system. The hepatitis B virus (HBV) and human papilloma virus (HPV) vaccines exploit the assembly competence of structural proteins, which are the effective immunogenic components of the prophylactic HBV and HPV vaccines, respectively. To optimize vaccine designs and to promote immune responses against protective epitopes, the "Asp-Ala-As...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Human Genetics Wt Centre
Department:
Unknown
Role:
Author
Publisher:
Elsevier
Journal:
Vaccine More from this journal
Volume:
37
Issue:
12
Pages:
1674-1684
Publication date:
2019-02-14
Acceptance date:
2019-01-18
DOI:
ISSN:
0264-410X
Pmid:
30773400
Language:
English
Keywords:
Pubs id:
pubs:1041943
UUID:
uuid:fa4e9db4-4c1c-4274-b394-b0877c2aa532
Local pid:
pubs:1041943
Source identifiers:
1041943
Deposit date:
2019-10-28

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