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Journal article

Targeted nNOS gene transfer into the cardiac vagus rapidly increases parasympathetic function in the pig.

Abstract:

Nitric oxide (NO) derived from neuronal nitric oxide synthase (nNOS) facilitates cardiac vagal neurotransmission and bradycardia in vitro. Here we provide evidence of rapid (within 9 h) protein expression and increased vagal responsiveness in vivo following targeted gene transfer of nNOS into the cardiac vagus of the pig. Right vagi were injected with vector encoding nNOS (Ad.nNOS) or saline, while left vagi received an injection of vector encoding enhanced green fluorescent protein (Ad.eGFP)...

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Publication status:
Published

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Publisher copy:
10.1016/j.yjmcc.2005.03.018

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Journal:
Journal of molecular and cellular cardiology
Volume:
39
Issue:
1
Pages:
159-164
Publication date:
2005-07-05
DOI:
EISSN:
1095-8584
ISSN:
0022-2828
URN:
uuid:fa4cfd31-f9e9-4038-a99f-c9eda8683991
Source identifiers:
105113
Local pid:
pubs:105113

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