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Journal article

Loss of RASSF1A synergizes with deregulated RUNX2 signaling in tumorigenesis.

Abstract:

The tumor suppressor gene RASSF1A is inactivated through point mutation or promoter hypermethylation in many human cancers. In this study, we conducted a Sleeping Beauty transposon-mediated insertional mutagenesis screen in Rassf1a-null mice to identify candidate genes that collaborate with loss of Rassf1a in tumorigenesis. We identified 10 genes, including the transcription factor Runx2, a transcriptional partner of Yes-associated protein (YAP1) that displays tumor suppressive activity throu...

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Publication status:
Published

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Authors


van der Weyden, L More by this author
Papaspyropoulos, A More by this author
Poulogiannis, G More by this author
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Journal:
Cancer research
Volume:
72
Issue:
15
Pages:
3817-3827
Publication date:
2012-08-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:fa46d0ba-8016-42f7-b8cc-5c6efbf2cd12
Source identifiers:
341146
Local pid:
pubs:341146

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