Post-exposure prophylaxis against SARS-CoV-2 in close contacts of confirmed COVID-19 cases (CORIPREV): study protocol for a cluster-randomized trial

Journal article

Background: Post-exposure prophylaxis (PEP) is a well-established strategy for the prevention of infectious diseases, in which recently exposed people take a short course of medication to prevent infection. The primary objective of the COVID-19 Ring-based Prevention Trial with lopinavir/ritonavir (CORIPREV-LR) is to evaluate the efficacy of a 14-day course of oral lopinavir/ritonavir as PEP against COVID-19 among individuals with a high-risk exposure to a confirmed case. ...

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Authors: Tan, DHS; Chan, AK; Jüni, P; Tomlinson, G; Daneman, N

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: BioMed Central
• Journal: Trials
• Volume: 22
• Issue: 1
• Pages: 224-224
• Article number: 224
• Publication date: 2021-03-22
• DOI: 10.1186/s13063-021-05134-7
• EISSN: 1745-6215
• ISSN: 1745-6215
• Language: English
• Keywords: Coronavirus disease 2019 (COVID-19); Immunology; Viral load; Clinical trial; Lopinavir; Randomized controlled trial; Ritonavir; Disease; Epidemiology; Human immunodeficiency virus (HIV); Internal medicine; Medicine; Infectious disease (medical specialty)