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Lentivector producer cell lines with stably expressed vesiculovirus envelopes

Abstract:

Retroviral and lentiviral vectors often use the envelope G protein from the vesicular stomatitis virus Indiana strain (VSVind.G). However, lentivector producer cell lines that stably express VSVind.G have not been reported, presumably because of its cytotoxicity, preventing simple scale-up of vector production. Interestingly, we showed that VSVind.G and other vesiculovirus G from the VSV New Jersey strain (VSVnj), Cocal virus (COCV), and Piry virus (PIRYV) could be constitutively expressed an...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.omtm.2018.07.013

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM Clinical Laboratory Sciences
Ferraresso, M More by this author
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Publisher:
Elsevier Publisher's website
Journal:
Molecular Therapy: Methods and Clinical Development Journal website
Volume:
10
Pages:
303-312
Publication date:
2018-08-07
Acceptance date:
2018-07-30
DOI:
EISSN:
2329-0501
Pubs id:
pubs:915480
URN:
uri:fa3fdeeb-b7df-4599-af14-638b66b32773
UUID:
uuid:fa3fdeeb-b7df-4599-af14-638b66b32773
Local pid:
pubs:915480
Language:
English
Keywords:

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