Journal article
Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans.
- Abstract:
-
The development of the mammalian brain is dependent on extensive neuronal migration. Mutations in mice and humans that affect neuronal migration result in abnormal lamination of brain structures with associated behavioral deficits. Here, we report the identification of a hyperactive N-ethyl-N-nitrosourea (ENU)-induced mouse mutant with abnormalities in the laminar architecture of the hippocampus and cortex, accompanied by impaired neuronal migration. We show that the causative mutation lies i...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.cell.2006.12.017
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Authors
Bibliographic Details
- Journal:
- Cell
- Volume:
- 128
- Issue:
- 1
- Pages:
- 45-57
- Publication date:
- 2007-01-01
- DOI:
- EISSN:
-
1097-4172
- ISSN:
-
0092-8674
- Source identifiers:
-
11060
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:11060
- UUID:
-
uuid:fa1d869a-5867-42d0-9d50-e0db75972918
- Local pid:
- pubs:11060
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2007
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