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Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans.

Abstract:

The development of the mammalian brain is dependent on extensive neuronal migration. Mutations in mice and humans that affect neuronal migration result in abnormal lamination of brain structures with associated behavioral deficits. Here, we report the identification of a hyperactive N-ethyl-N-nitrosourea (ENU)-induced mouse mutant with abnormalities in the laminar architecture of the hippocampus and cortex, accompanied by impaired neuronal migration. We show that the causative mutation lies i...

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Publication status:
Published

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Publisher copy:
10.1016/j.cell.2006.12.017

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
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Journal:
Cell
Volume:
128
Issue:
1
Pages:
45-57
Publication date:
2007-01-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:fa1d869a-5867-42d0-9d50-e0db75972918
Source identifiers:
11060
Local pid:
pubs:11060

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