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Neisseria meningitidis lactate permease is required for nasopharyngeal colonization.

Abstract:

Neisseria meningitidis is a human specific pathogen that is part of the normal nasopharyngeal flora. Little is known about the metabolic constraints on survival of the meningococcus during colonization of the upper airways. Here we show that glucose and lactate, both carbon energy sources for meningococcal growth, are present in millimolar concentrations within nasopharyngeal tissue. We used a mutant defective for the uptake of lactate (C311DeltalctP) to investigate the contribution of this e...

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Journal:
Infection and immunity More from this journal
Volume:
73
Issue:
9
Pages:
5762-5766
Publication date:
2005-09-01
DOI:
EISSN:
1098-5522
ISSN:
0019-9567
Language:
English
Keywords:
Pubs id:
pubs:249497
UUID:
uuid:f9d56a48-c7a1-4500-9bb1-1be223d670d0
Local pid:
pubs:249497
Source identifiers:
249497
Deposit date:
2012-12-19

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