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Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19

Abstract:

While it is now widely accepted that host inflammatory responses contribute to lung injury, the pathways that drive severity and distinguish coronavirus disease 2019 (COVID-19) from other viral lung diseases remain poorly characterized. We analyzed plasma samples from 471 hospitalized patients recruited through the prospective multicenter ISARIC4C study and 39 outpatients with mild disease, enabling extensive characterization of responses across a full spectrum of COVID-19 severity. Progressi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0003-3052-2793
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Role:
Author
ORCID:
0000-0002-1979-1805
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Role:
Author
ORCID:
0000-0003-2504-6518
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Role:
Author
ORCID:
0000-0002-8736-9198
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Role:
Author
ORCID:
0000-0002-9873-8243

Contributors

Role:
Contributor
Publisher:
American Association for the Advancement of Science
Journal:
Science Immunology More from this journal
Volume:
6
Issue:
57
Article number:
eabg9873
Place of publication:
United States
Publication date:
2021-03-10
Acceptance date:
2021-03-05
DOI:
EISSN:
2470-9468
Pmid:
33692097
Language:
English
Keywords:
Pubs id:
1168499
Local pid:
pubs:1168499
Deposit date:
2021-05-11

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