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TLR signaling in human antigen-presenting cells regulates MR1-dependent activation of MAIT cells

Abstract:

Mucosal-associated invariant T (MAIT) cells are an abundant innate-like T lymphocyte population that are enriched in liver and mucosal tissues. They are restricted by MR1, which presents antigens derived from a metabolic precursor of riboflavin synthesis, a pathway present in many microbial species, including commensals. Therefore, MR1-mediated MAIT cell activation must be tightly regulated to prevent inappropriate activation and immunopathology. Using an in vitro model of MR1-mediated activa...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/eji.201545969

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Department:
Oxford, MSD, NDM
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Department:
Oxford, MSD, NDM
Hannaway, RF More by this author
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Department:
Oxford, MSD, NDM
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Department:
Oxford, MSD, NDM
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Publisher:
Wiley Publisher's website
Journal:
European journal of immunology Journal website
Volume:
46
Issue:
7
Pages:
1600-1614
Publication date:
2016-05-30
Acceptance date:
2016-08-02
DOI:
ISSN:
0014-2980 and 1521-4141
Pubs id:
pubs:619507
URN:
uri:f9a522bb-6661-4b0e-ae1c-d016c505aae2
UUID:
uuid:f9a522bb-6661-4b0e-ae1c-d016c505aae2
Local pid:
pubs:619507

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