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Efficacy and day 7 plasma piperaquine concentrations in African children treated for uncomplicated malaria with dihydroartemisinin-piperaquine

Abstract:

Background One promising new Artemisinin-based combination therapies (ACTs) is dihydroartemisinin-piperaquine (DHA-PQ). However, the pharmacokinetics of piperaquine and the relationship between drug levels and clinical efficacy are incompletely characterized, particularly in children. Methods We performed a single-arm open-label trial in Bobo-Dioulasso, Burkina Faso. A total of 379 participants aged 6 months or more with uncomplicated falciparum malaria were enrolled. Each participant receive...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0103200

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Publisher:
Public Library of Science
Journal:
PloS ONE More from this journal
Volume:
9
Issue:
8
Pages:
ARTN e103200
Publication date:
2014-08-18
Acceptance date:
2014-06-24
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Language:
English
Keywords:
Pubs id:
pubs:480191
UUID:
uuid:f99ee180-9bac-4620-bf9c-2ee9a1b01bfe
Local pid:
pubs:480191
Source identifiers:
480191
Deposit date:
2014-08-21

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