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Dynamic coinfection with multiple viral subtypes in acute hepatitis C.

Abstract:

INTRODUCTION: Acute hepatitis C virus (HCV) infection is rarely studied, but virus sequence evolution and host-virus dynamics during this early stage may influence the outcome of infection. Hypervariable region 1 (HVR1) is genetically diverse and under selective pressure from the host immune response. We analyzed HVR1 evolution by frequent sampling of an acutely infected HCV cohort. METHODS: Three or more pretreatment samples were obtained from each of 10 acutely infected subjects. Polymeras...

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Publication status:
Published

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Publisher copy:
10.1086/657317

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Journal:
Journal of infectious diseases More from this journal
Volume:
202
Issue:
12
Pages:
1770-1779
Publication date:
2010-12-01
DOI:
EISSN:
1537-6613
ISSN:
0022-1899

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