Pharmacokinetics of oral doxycycline during combination treatment of severe falciparum malaria.

Journal article

The pharmacokinetics of oral doxycycline administered at 200 mg every 24 h were investigated in 17 patients recovering from severe Plasmodium falciparum malaria. The data suggest that the doses of doxycycline currently recommended (circa 3.5 mg/kg of body weight daily) may not be optimal.

Authors: Newton, P; Chaulet, J; Brockman, A; Chierakul, W; Dondorp, A

• Publication status: Published
• Journal: Antimicrobial agents and chemotherapy
• Volume: 49
• Issue: 4
• Pages: 1622-1625
• Publication date: 2005-04-01
• DOI: 10.1128/aac.49.4.1622-1625.2005
• EISSN: 1098-6596
• ISSN: 0066-4804
• Language: English
• Keywords: Sesquiterpenes; Humans; Animals; Middle Aged; Drug Therapy, Combination; Adult; Doxycycline; Plasmodium falciparum; Adolescent; Antimalarials; Administration, Oral; Artemisinins; Female; Male; Malaria, Falciparum; Aged; Severity of Illness Index